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Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017

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Adler, Hugh ORCID: https://orcid.org/0000-0003-4437-2298, Nikolaou, Elissavet, Gould, Katherine, Hinds, Jason, Collins, Andrea ORCID: https://orcid.org/0000-0002-4094-1572, Connor, Victoria, Hales, Caz, Hill, Helen, Hyder-Wright, Angela, Zaidi, Seher, German, Esther, Gritzfeld, Jenna, Mitsi, Elena, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116, Roberts, Adam, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611 and Ferreira, Daniela ORCID: https://orcid.org/0000-0001-7730-9477 (2019) 'Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010—2017'. Journal of Infectious Disease. (In Press)

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Abstract

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (non-smokers without major comorbidities or contact with children under five years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% (52/795) of volunteers. Serotype 3 was the commonest serotype (10/52). The majority of the remainder (35/52) were non-vaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least one of six antibiotics tested was found in 8/52 isolates.

Item Type: Article
Subjects: WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 202 Pneumonia (General or not elsewhere classified)
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 210 Streptococcal infections (General or not elsewhere classified)
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WF Respiratory System > Lungs > WF 600 Lungs
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1093/infdis/jiz034
Depositing User: Stacy Murtagh
Date Deposited: 04 Feb 2019 13:09
Last Modified: 11 Apr 2019 09:41
URI: http://archive.lstmed.ac.uk/id/eprint/10018

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