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Reliability of rapid testing for hepatitis B in a region of high HIV endemicity

Davies, J., van Oosterhout, J.J., Nyirenda, M., Bowden, J., Moore, E., Hart, I.J., Zijlstra, E.E., Chaponda, M., Faragher, Brian, Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791 and Beadsworth, M. (2010) 'Reliability of rapid testing for hepatitis B in a region of high HIV endemicity'. Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol 104, Issue 2, pp. 162-164.

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Abstract

Hepatitis B (HBV) and HIV co-infection is common in resource-poor settings. A recent study from Malawi revealed poor correlation between hepatitis B surface antigen (HBsAg) point-of-care tests and reference tests in patients co-infected with HIV. We studied a cohort of 300 Malawian adults entering a treatment programme for HIV. Sera were tested for HBsAg first using the Determine rapid test and re-tested using a commercial enzyme immunoassay (EIA). All tests were done under optimal conditions in Liverpool, UK. Sera from all 25 patients positive for HBsAg using the rapid test and from 50 who were negative, were re-tested using the EIA, with complete concordance of results. The κ correlation was 1, specificity 100% (93–100%) and sensitivity 100% (86–100%) compared to the reference test. Patients had advanced immune suppression (mean CD4 = 175 cells × 106/l). In a non-field setting, the results of point-of-care Determine rapid hepatitis B tests appear reliable in patients with HIV-1 co-infection.

Item Type: Article
Uncontrolled Keywords: hepatitis B, HIV, Co-infection, Diagnosis, Point-of-care test, Malawi
Subjects: WA Public Health > WA 30 Socioeconomic factors in public health (General)
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 536 Human viral hepatitis
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.trstmh.2009.10.010
Depositing User: Users 43 not found.
Date Deposited: 02 Jul 2010 11:51
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/1024

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