LSTM Home > LSTM Research > LSTM Online Archive

Nonspecific effects of oral vaccination with live-attenuated Typhi strain Ty21a

Downloads

Downloads per month over past year

Pennington, Shaun ORCID: https://orcid.org/0000-0002-7160-6275, Ferreira, Daniela ORCID: https://orcid.org/0000-0001-7730-9477, Caamaño-Gutiérrez, E, Reiné, Jesús, Hewitt, C, Hyder-Wright, Angela, Gordon, Stephen ORCID: https://orcid.org/0000-0001-6576-1116 and Gordon, Melita (2019) 'Nonspecific effects of oral vaccination with live-attenuated Typhi strain Ty21a'. Science Advances, Vol 5, Issue 2, eaau6849.

[img]
Preview
Text
Pennington-Sci-Adv-March-19.pdf - Published Version
Available under License Creative Commons Attribution.

Download (4MB) | Preview

Abstract

Epidemiological and immunological evidence suggests that some vaccines can reduce all-cause mortality through nonspecific changes made to innate immune cells. Here, we present the first data to describe the nonspecific immunological impact of oral vaccination with live-attenuated Typhi strain Ty21a. We vaccinated healthy adults with Ty21a and assessed aspects of innate and adaptive immunity over the course of 6 months. Changes to monocyte phenotype/function were observed for at least 3 months. Changes to innate and adaptive immune cell cytokine production in response to stimulation with vaccine and unrelated nonvaccine antigens were observed over the 6-month study period. The changes that we have observed could influence susceptibility to infection through altered immune responses mounted to subsequently encountered pathogens. These changes could influence all-cause mortality.

Item Type: Article
Subjects: QW Microbiology and Immunology > Bacteria > QW 138 Enterobacteriaceae
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1126/sciadv.aau6849
Depositing User: Stacy Murtagh
Date Deposited: 11 Mar 2019 11:36
Last Modified: 14 Mar 2019 12:34
URI: http://archive.lstmed.ac.uk/id/eprint/10345

Statistics

View details

Actions (login required)

Edit Item Edit Item