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Assessing disability after encephalitis: development of a new outcome score in India and Malaysia

Lewthwaite, Penny, Begum, Ashia, Ooi, Mung How, Faragher, Brian, Lai, Boon oo, Sandaradura, Indunil, Mohan, Anand, Mandhan, Gaurav, Meharwade, Pratibha, Subhashini, Abhishek, Gulia, Begum, Asma, Penkulinti, Srihari, Shankar, M. Veera, Ravikumar, R., Young, Carolyn, Cardosa, Mary Jane, Ravi, V., Chang Wong, See, Kneen, Rachel and Solomon, Tom (2010) 'Assessing disability after encephalitis: development of a new outcome score in India and Malaysia'. Bulletin of the World Health Organization, Vol 88, Issue 8.

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Abstract

Objective To develop a simple tool for assessing the severity of disability
resulting from Japanese encephalitis and whether, as a result, a child is likely
to be dependent.
Methods A new outcome score based on a 15-item questionnaire was
developed after a literature review, examination of current assessment tools,
discussion with experts and a pilot study. The score was used to evaluate 100
children in Malaysia (56 Japanese encephalitis patients and 44 controls) and
95 in India (36 Japanese encephalitis patients, 41 patients with encephalitis of
unknown etiology and 18 controls). Inter- and intra-observer variability in the
outcome score was determined and the score was compared with full clinical
assessment.
Findings There was good inter-observer agreement on using the new
score to identify likely dependency (κ = 0.942 for Malaysian children;
κ = 0.786 for Indian children) and good intra-observer agreement (κ = 1.000
and 0.902, respectively). In addition, agreement between the new score and
clinical assessment was also good (κ = 0.906 and 0.762, respectively). The
sensitivity and specificity of the new score for identifying children likely to be
dependent were 100% and 98.4% in Malaysia and 100% and 93.8% in India.
Publication: Bulletin of the World Health Organization; Type: Research
Article DOI: 10.2471/BLT.09.071357
26
Positive and negative predictive values were 84.2% and 100% in Malaysia
and 65.6% and 100% in India.
Conclusion The new tool for assessing disability in children after
Japanese encephalitis was simple to use and scores correlated well with
clinical assessment.

Item Type: Article
Subjects: WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 542 Arbovirus encephalitis. Equine encephalomyelitis (in humans)
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.2471/BLT.09.071357
Depositing User: Users 43 not found.
Date Deposited: 15 Jul 2010 13:41
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/1037

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