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Clinical characteristics and treatment outcome of patients with visceral leishmaniasis and HIV co-infection in northwest Ethiopia

Hurissa, Zewdu, Gebre-Silassie, Samuel, Hailu, Workagegnehu, Tefera, Tewodros, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 and Hailu, Asrat (2010) 'Clinical characteristics and treatment outcome of patients with visceral leishmaniasis and HIV co-infection in northwest Ethiopia'. Tropical Medicine & International Health, Vol 15, Issue 7, pp. 848-855.

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Abstract

objectives To describe the clinical presentation of patients with visceral leishmaniasis (VL) with
and without human immunodeficiency virus (HIV) co-infection and factors associated with poor
outcome in northwest Ethiopia.
method Retrospective review of 241 patients with VL (92 with and 149 without HIV co-infection).
results HIV co-infection was present in 92 (38%) of the patients. Clinical presentation of VL was
indistinguishable between patients with and without HIV co-infection. Co-infected patients had a poorer
outcome i.e. either death or treatment failure (31.5% vs. 5.6%, P < 0.001). The presence of tuberculosis
or sepsis syndrome among patients with VL and HIV co-infected independently predicted death or
treatment failure [odds ratio 4.5 (95% CI 1.47–13.92, P = 0.009) and 9.1 (95% CI 2.16–37.97,
P = 0.003), respectively]. Despite having similar clinical presentation at the time of diagnosis, VL and
HIV co-infected patients had a higher mortality and treatment failure than immunocompetent patients.
conclusion The frequency of HIV co-infection among patients with VL is high in the study area, and
this co-infection was associated with death or treatment failure. The clinical management of VL in HIV
co-infected patients is a major challenge that requires new treatment approaches to improve its outcome

Item Type: Article
Uncontrolled Keywords: visceral leishmaniasis, HIV and VL co-infection, treatment outcome, northwest Ethiopia
Subjects: WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.41 General coverage
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-3156.2010.02550.x
Depositing User: Users 43 not found.
Date Deposited: 09 Jul 2010 09:27
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/1044

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