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Favourable one-year ART outcomes in adult Malawians with hepatitis B and C co-infection

Moore, E., Beadsworth, M., Chaponda, M., Mhango, B., Faragher, Brian, Njala, J., Hofland, H.W.C., Davies, J., Hart, I.J., Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791, Zijlstra, E.E. and van Oosterhout, J.J. (2010) 'Favourable one-year ART outcomes in adult Malawians with hepatitis B and C co-infection'. Journal of Infection, Vol 61, pp. 155-163.

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Abstract

Background
Few studies have investigated the impact of chronic hepatitis B and C infection on antiretroviral therapy (ART) outcomes in sub-Saharan Africa. Hepatotoxicity may be a particular concern in co-infected patients taking nevirapine–stavudine–lamivudine.
Methods
We conducted a prospective cohort study of 300 Malawian adults starting ART and describe one-year ART outcomes according to viral hepatitis status.
Results
At baseline, patients had advanced HIV disease (29.3% were in WHO stage 4; mean CD4 = 157 cells/μL; mean log10HIV-1 RNA = 5.24 copies/ml). Co-infection with hepatitis B, C and B + C were present in 6.7%, 5.7% and 1.7% respectively. At 50 weeks, all-cause mortality was 43 (14.3%). Sixteen (5.3%) had transferred to another unit. Eight (2.7%) were lost to follow up. Sixteen (5.3%) had stopped ART. 217 (72.3%) were alive on ART, of whom 82.5% had an HIV-1 RNA <400 copies/ml at week 50. During the first 50 weeks of ART, severe hepatotoxicity (liver enzyme values >5 times upper level of normal) occurred in 9%, but did not result in any ART discontinuations. Clinical hepatitis or jaundice was not observed. There were no significant differences in occurrence of hepatotoxicity, other side effects, mortality, severe morbidity, immune reconstitution or virological failure between hepatitis B and/or C co-infected patients and those who were not. Viral hepatitis co-infection was not associated with severe hepatotoxicity, mortality, severe morbidity or virological failure in multivariate analyses.
Conclusion
Our data suggest that screening for viral hepatitis B and C and liver enzyme monitoring may not require high priority in ART programmes in sub-Saharan Africa.

Item Type: Article
Uncontrolled Keywords: HIV; Malawi; ART; Hepatitis B and C; Hepatotoxicity
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 268.5 Antiviral agents (General)
WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 536 Human viral hepatitis
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.jinf.2010.04.009
Depositing User: Users 43 not found.
Date Deposited: 26 Jul 2010 09:09
Last Modified: 06 Feb 2018 13:00
URI: http://archive.lstmed.ac.uk/id/eprint/1081

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