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The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya.

Hassall, Oliver, Maitland, Kathryn, Fegan, Gregory, Thitiri, Johnstone, Pole, Lewa, Mwakesi, Robert, Denje, Douglas, Wambua, Kongo, Mandaliya, Kishor and Bates, Imelda ORCID: https://orcid.org/0000-0002-0862-8199 (2010) 'The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya.'. Transfusion, Vol 50, Issue 3, pp. 611-6.

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Abstract

BACKGROUND: In sub-Saharan Africa umbilical cord blood may be a useful source of blood for transfusion. Before clinical trials, evidence is needed that cord blood donations, which vary greatly in volume, can be collected and stored into a fixed volume of anticoagulant-preservative solution obviating the need for prestorage processing. STUDY DESIGN AND METHODS: Twenty-four umbilical cord whole blood (UC-WB) donations were collected into 21 mL of CPDA-1 and refrigerated for 35 days. The Kenya Blood Transfusion Service provided 12 adult-donated whole blood (AD-WB) controls. Supernatant hemoglobin (Hb) and potassium were assayed at 7-day intervals. RESULTS: UC-WB red blood cell hemolysis and potassium loss increased throughout storage but did not differ significantly with cord blood volume. Hemolysis rates did not differ significantly between UC-WB and AD-WB but UC-WB potassium loss was slightly but significantly greater than AD-WB on Days 2, 7, and 14 (p < 0.05). In the AD-WB controls, eight were low volume (<405 mL), two had total Hb of less than 45 g, and two showed hemolysis greater than 0.8% by Day 28. CONCLUSION: Variable volumes of UC-WB can be stored for 35 days without prestorage processing and further work into its suitability for transfusion to children is justified. The quality of conventional AD-WB is a concern and needs further evaluation.

Item Type: Article
Subjects: WB Practice of Medicine > Therapeutics > WB 300 General works
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 450 Whole blood. Blood derivatives. Plasma substitutes. Blood expanders
Faculty: Department: Groups (2002 - 2012) > Disease Control Strategy Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1537-2995.2009.02489.x
Depositing User: Tina Bowers
Date Deposited: 19 Aug 2010 09:32
Last Modified: 06 Feb 2018 13:01
URI: https://archive.lstmed.ac.uk/id/eprint/1133

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