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Pyrethroid resistance in Aedes aegypti from Grand Cayman.

Harris, Angela F., Rajatileka, Shavanthi and Ranson, Hilary ORCID: 0000-0003-2332-8247 (2010) 'Pyrethroid resistance in Aedes aegypti from Grand Cayman.'. American Journal of Tropical Medicine and Hygiene, Vol 83, Issue 2, pp. 277-284.

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Abstract

The Grand Cayman population of Aedes aegypti is highly resistant to DDT and pyrethroid insecticides. Glutathione transferase, cytochrome P450, and esterase levels were increased in the Grand Cayman population relative to a susceptible laboratory strain, but synergist studies did not implicate elevated insecticide detoxification as a major cause of resistance. The role of target site resistance was therefore investigated. Two substitutions in the voltage-gated sodium channel were identified, V1016I in domain II, segment 6 (IIS6) (allele frequency = 0.79) and F1534C in IIIS6 (allele frequency = 0.68). The role of the F1534C mutation in conferring resistance to insecticides has not been previously established and so a tetraplex polymerase chain reaction assay was designed and used to genotype mosquitoes that had been exposed to insecticides. The F1534C mutation was strongly correlated with resistance to DDT and permethrin.

Item Type: Article
Subjects: QW Microbiology and Immunology > Immunity by Type > QW 551 Acquired immunity. Artificial immunity
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 800 Biological products producing immunity
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 525 Aedes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.4269/ajtmh.2010.09-0623
Depositing User: Users 183 not found.
Date Deposited: 24 Aug 2010 10:59
Last Modified: 28 Sep 2018 15:33
URI: http://archive.lstmed.ac.uk/id/eprint/1143

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