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Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies

Bates, Paul (2007) 'Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies'. International Journal for Parasitology, Vol 37, Issue 10, pp. 1097-1106.

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Abstract

A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promastigote secretory gel (PSG) by the parasites in the anterior midgut. This forces the sand fly to regurgitate PSG before it can bloodfeed, thereby depositing both PSG and infective metacyclic promastigotes in the skin of a mammalian host. Other possible factors in transmission are considered: damage to the stomodeal valve; occurrence of parasites in the salivary glands; and excretion of parasites from the anus of infected sand flies. Differences in the transmission mechanisms employed by parasites in the three subgenera, Leishmania, Viannia and Sauroleishmania are also addressed. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: Invited review.
Uncontrolled Keywords: leishmania viannia life cycle promastigote secretory gel metacyclic promastigotes regurgitation sand fly saliva lutzomyia-longipalpis cutaneous leishmaniasis parasite transmission sandflies diptera fly saliva psychodidae vector braziliensis bite infections
Subjects: QX Parasitology > QX 45 Host-parasite relations
QX Parasitology > Insects. Other Parasites > QX 505 Diptera
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 715 Visceral leishmaniasis
WR Dermatology > Parasitic Skin Diseases > WR 350 Tropical diseases of the skin. Mucocutaneous leishmaniasis. Leishmaniasis
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ijpara.2007.04.003
Depositing User: Ms Julia Martin
Date Deposited: 02 Sep 2010 15:28
Last Modified: 06 Feb 2018 13:01
URI: https://archive.lstmed.ac.uk/id/eprint/1166

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