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Same-day smears in the diagnosis of tuberculosis

Hirao, S., Yassin, Mohammed A., Khamofu, H. G., Lawson, Lovett, Cambanis, A., Ramsay, Andrew and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2007) 'Same-day smears in the diagnosis of tuberculosis'. Tropical Medicine & International Health, Vol 12, Issue 12, pp. 1459-1463.

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Abstract

OBJECTIVE To assess the feasibility of completing the diagnosis of tuberculosis (TB) in 1 day by collecting only on-the-spot specimens.
METHODS Individuals with suspected TB attending district hospitals in Abuja submitted three sputum samples for routine diagnosis (the standard approach). One additional sample was collected 1 h after the first sputum (the same-day approach). One sputum sample was cultured. Blood samples were tested for HIV.
RESULTS Two hundred and twenty-four patients with chronic cough had 135/672 (20%) positive on-the-spot smears and 47/224 (21%) positive morning smears. The same-day and internationally recommended approaches identified 44 and 45 of the 78 patients with positive cultures, respectively. 106/194 (55%) patients were HIV positive. Only 9-11% of their smears were positive compared with 30-32% for HIV negatives (P < 0.01).
CONCLUSON It could be possible to diagnose TB in a single day by examining two spot specimens, but the feasibility needs to be confirmed on a larger scale.

Item Type: Article
Uncontrolled Keywords: tuberculosis diagnosis same day hiv nigeria scanty afb smears pulmonary tuberculosis microscopy ethiopia culture hiv
Subjects: QY Clinical Pathology > Diagnostic Tests > QY 120 Sputum
WF Respiratory System > Tuberculosis > WF 220 Diagnosis. Prognosis
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-3156.2007.01952.x
Depositing User: Pauline Anderson
Date Deposited: 23 Nov 2010 10:41
Last Modified: 06 Feb 2018 13:01
URI: https://archive.lstmed.ac.uk/id/eprint/1212

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