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The Yin and Yang of linkage disequilibrium: mapping of genes and nucleotides conferring insecticide resistance in insect disease vectors.

Black, William C, Gorrochetegui-Escalante, Norma, Randle, Nadine P. and Donnelly, Martin ORCID: https://orcid.org/0000-0001-5218-1497 (2008) 'The Yin and Yang of linkage disequilibrium: mapping of genes and nucleotides conferring insecticide resistance in insect disease vectors.' in: Transgenesis and the Management of Vector-Borne Disease, 627, New York, Springer, pp. 71-83.

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Abstract

Genetic technologies developed in the last 20 years have lead to novel and exciting methods to identify genes and specific nucleotides within genes that control phenotypes in field collected organisms. In this review we define and explain two of these methods: linkage disequilibrium (LD) mapping and quantitative trait nucleotide (QTN) mapping. The power to detect valid genotype-phenotype associations with LD or QTN mapping depends critically on the extent to which segregating sites in a genome assort independently. LD mapping depends on markers being in disequilibrium with the genes that condition expression of the phenotype. In contrast, QTN mapping depends critically upon most proximal loci being at equilibrium. We show that both patterns actually exist in the genome of Anapheles gambiae, the most important malaria vector in sub-Saharan Africa while segregating sites appear to be largely in equilibrium throughout the genome of Aedes aegypti, the vector of Dengue and Yellow fever flaviviruses. We discuss additional approaches that will be needed to identify genes and nucleotides that control phenotypes in field collected organisms, focusing specifically on ongoing studies of genes conferring resistance to insecticides.

Item Type: Book Section
Subjects: QU Biochemistry > Genetics > QU 475 Genetic processes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1007/978-0-387-78225-6_6
Depositing User: Users 183 not found.
Date Deposited: 26 Aug 2010 14:01
Last Modified: 06 Feb 2018 13:01
URI: http://archive.lstmed.ac.uk/id/eprint/1313

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