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The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial

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Zhang, Chunxiao, Zheng, Yaguang, Chen, Tao ORCID: https://orcid.org/0000-0002-5489-6450, Wang, Shengyu and Xu, Meng (2019) 'The utility of traditional Chinese medicine (Shenmai) in the cardiac rehabilitation after coronary artery bypass grafting: A single-center randomized clinical trial'. Complementary Therapies in Medicine, Vol 47, Issue 102203.

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The Utility of Traditional Chinese Medicine (Shenmai) in the Cardiac Rehabilitation after Coronary Artery Bypass Grafting a Single-Center Randomized Clin (002).pdf - Accepted Version
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Abstract

Objective
examine the efficacy and safety of Shenmai to the cardiac rehabilitation in patients received coronary artery bypass grafting.
Design
a single-center randomized, single blind clinical trial.
Setting
Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Subjects
Patients with coronary artery disease who received coronary artery bypass grafting in our center were studied. They must be competent to complete the 6-minute walking test without any assistance and without any severe comorbidity.
Interventions
in Shemmai group, the participants were treated with Shenmai injection (100 ml/day) right after the surgery to discharge for 9.28 ± 3.75 days and then capsule (3.6 g/day) sequentially for 30 days in addition to the cardiac rehabilitation. In control group, only cardiac rehabilitation was conducted.
Main measures
the 6-Minute Walking Test was measured at three time points: one day before operation, on the day of discharge and 30 days follow up.
Results
The sample (n = 166) was predominately male (84%), with mean age was 61.12 ± 9.13 years. There was no significant difference between groups in baseline characteristics and the procedural characteristics. There was one death in control group and one stroke in Shenmai group right after the surgery. Overall, there was group (p = .005) and time effect (p < .001) on the 6-minute walking distance. Participants in the Shenmai group walked longer distance in meters compared with control group on the day of discharge (314.54 ± 64.14 vs. 271.29 ± 76.82, P < .001), while no significant differences before operation (399.72 ± 93.19 vs. 403.67 ± 91.99, p = .78) and on 30-day follow up (436.54 ± 67.64 vs. 421.64 ± 83.53, p = .21).
Conclusion
Shenmai improves the exercise tolerance in the early stage of the cardiac rehabilitation for patients received coronary artery bypass grafting.

Item Type: Article
Subjects: WB Practice of Medicine > WB 102.5 Clinical medicine - evidence-based practice
WB Practice of Medicine > Traditional medicine > WB 55.C4 Chinese traditional medicine
WG Cardiovascular System > WG 20 Research (General)
WG Cardiovascular System > Heart. Heart Diseases > WG 200 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ctim.2019.102203
Depositing User: Christine Bradbury
Date Deposited: 11 Dec 2019 10:35
Last Modified: 11 Dec 2019 10:35
URI: https://archive.lstmed.ac.uk/id/eprint/13291

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