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Treatment of childhood Plasmodium falciparum malaria: current challenges

Bell, David J. and Molyneux, Malcolm E (2007) 'Treatment of childhood Plasmodium falciparum malaria: current challenges'. Expert Review of Anti-Infective Therapy, Vol 5, Issue 1, pp. 141-152.

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Abstract

Malaria continues to be a major cause of mortality and morbidity in tropical countries. Infection with Plasmodium falciparum may be asymptomatic, cause an uncomplicated febrile illness or give rise to severe disease complicated by coma, acidosis or severe anemia. Treatment of the febrile illness with two drugs - preferably in the form of an artemisinin-containing combination therapy - is now widely recommended, both for greater efficacy and in order to delay the evolution of drug resistance. The clinical picture of severe malaria differs according to the age and immune status of the individual; treatment requires a range of supportive measures, as well as an efficacious antimalarial drug. Insecticide-treated bednets and presumptive treatment programs are increasingly deployed in malaria control programs, while vaccines are showing promise.

Item Type: Article
Additional Information: <Go to ISI>://000253781000023. DOI maybe incorrect, JM, 26/7/10
Uncontrolled Keywords: complications diagnosis ipt malaria plasmodium falciparum rapid diagnostic tests treatment randomized controlled-trial moderately severe malaria placebo-controlled trial adverse drug-reactions african children cerebral malaria artemether-lumefantrine sulfadoxine-pyrimethamine malawian children mefloquine resistance
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 765 Prevention and control
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
Faculty: Department: Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1586/14787210.5.1.141
Depositing User: Ms Julia Martin
Date Deposited: 02 Sep 2010 14:22
Last Modified: 06 Feb 2018 13:01
URI: https://archive.lstmed.ac.uk/id/eprint/1343

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