A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies

Abrams, Simon, Morton, Ben ORCID: https://orcid.org/0000-0002-6164-2854, Alhamdi, Yasir, Alsabani, Mohmad, Cheng, Zhenxing, Lane, Steven, Welters, Ingeborg, Wang, Guozheng and Toh, Cheng-hock (2019) 'A novel assay of Neutrophil Extracellular Traps (NETs) formation independently predicts DIC and identifies the rationale for anti-IL-8 therapies'. Blood, Vol 134, Issue 1.

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Abstract

Neutrophils are the first line of defence against bacterial infection and formation of neutrophil extracellular traps (NETs) is an important protective mechanism. However, NETs can also cause harm by promoting intravascular coagulation and multi-organ failure (MOF) in animal models. Although increasingly considered as important therapeutic targets, there is currently no robust and specific measure of NETs formation to inform clinical care and enable precision medicine in patients on the intensive care unit (ICU). The aim of this study is to establish a novel assay for measuring NETs and assess its clinical significance.

Item Type:	Article
Subjects:	QY Clinical Pathology > Blood. Blood Chemistry > QY 450 Blood chemistry WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 200 Leukocytes. Leukocyte disorders (General) WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 322 Blood coagulation disorders (General) WX Hospitals and Other Health Facilities > Clinical Departments and Units > WX 200 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1182/blood-2019-128493
Depositing User:	Catherine Molloy
Date Deposited:	25 Feb 2020 13:38
Last Modified:	13 Nov 2020 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/13829

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