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Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing

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James, Stephanie L., Marshall, John N., Christophides, George K., Okumu, Fredros O. and Nolan, Tony ORCID: https://orcid.org/0000-0002-2982-8333 (2020) 'Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing'. Vector-Borne and Zoonotic Diseases, Vol 20, Issue 4, pp. 237-251.

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Abstract

Mosquitoes containing gene drive systems are being developed as complementary tools to prevent transmission of malaria and other mosquito-borne diseases. As with any new tool, decision makers and other stakeholders will need to balance risks (safety) and benefits (efficacy) when considering the rationale for testing and deploying gene drive-modified mosquito products. Developers will benefit from standards for judging whether an investigational gene drive product meets acceptability criteria for advancing to field trials. Such standards may be formalized as preferred product characteristics and target product profiles, which describe the desired attributes of the product category and of a particular product, respectively. This report summarizes discussions from two scientific workshops aimed at identifying efficacy and safety characteristics that must be minimally met for an investigational gene drive-modified mosquito product to be deemed viable to move from contained testing to field release and the data that will be needed to support an application for first field release.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1089/vbz.2019.2606
Depositing User: Mel Finley
Date Deposited: 25 Mar 2020 12:28
Last Modified: 09 Apr 2020 13:53
URI: https://archive.lstmed.ac.uk/id/eprint/14052

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