LSTM Home > LSTM Research > LSTM Online Archive

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.

Downloads

Downloads per month over past year

Michael, D R, Jack, A A, Masetti, G, Davies, T S, Loxley, K E, Kerry-Smith, J, Plummer, J F, Marchesi, J R, Mullish, B H, McDonald, J A K, Hughes, T R, Wang, Duolao ORCID: https://orcid.org/0000-0003-2788-2464, Garaiova, I, Paduchová, Z, Muchová, J, Good, M A and Plummer, S F (2020) 'A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being.'. Scientific Reports, Vol 10, Issue 1, e4183.

[img]
Preview
Text
PROMAGEN Scientific Reports 2020.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

In an exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study (ISRCTN12562026, funded by Cultech Ltd), 220 Bulgarian participants (30 to 65 years old) with BMI 25-34.9 kg/m received Lab4P probiotic (50 billion/day) or a matched placebo for 6 months. Participants maintained their normal diet and lifestyle. Primary outcomes were changes in body weight, BMI, waist circumference (WC), waist-to-height ratio (WtHR), blood pressure and plasma lipids. Secondary outcomes were changes in plasma C-reactive protein (CRP), the diversity of the faecal microbiota, quality of life (QoL) assessments and the incidence of upper respiratory tract infection (URTI). Significant between group decreases in body weight (1.3 kg, p < 0.0001), BMI (0.045 kg/m, p < 0.0001), WC (0.94 cm, p < 0.0001) and WtHR (0.006, p < 0.0001) were in favour of the probiotic. Stratification identified greater body weight reductions in overweight subjects (1.88%, p < 0.0001) and in females (1.62%, p = 0.0005). Greatest weight losses were among probiotic hypercholesterolaemic participants (-2.5%, p < 0.0001) alongside a significant between group reduction in small dense LDL-cholesterol (0.2 mmol/L, p = 0.0241). Improvements in QoL and the incidence rate ratio of URTI (0.60, p < 0.0001) were recorded for the probiotic group. No adverse events were recorded. Six months supplementation with Lab4P probiotic resulted in significant weight reduction and improved small dense low-density lipoprotein-cholesterol (sdLDL-C) profiles, QoL and URTI incidence outcomes in overweight/obese individuals.

Item Type: Article
Subjects: QU Biochemistry > Vitamins > QU 145.5 Nutritive values of food
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Nutrition Disorders > WD 100 General works
WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Metabolic Diseases > General Metabolic Diseases > WD 200 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1038/s41598-020-60991-7
Depositing User: Julie Franco
Date Deposited: 08 Apr 2020 10:44
Last Modified: 09 Apr 2020 10:14
URI: https://archive.lstmed.ac.uk/id/eprint/14139

Statistics

View details

Actions (login required)

Edit Item Edit Item