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A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations

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Brown, Faye, Paton, Douglas, Catteruccia, Flaminia, Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 and Ingham, Victoria ORCID: https://orcid.org/0000-0001-5708-4741 (2020) 'A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations'. Insect Biochemistry and Molecular Biology. (In Press)

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Abstract

Insecticide based vector control tools such as insecticide treated bednets and indoor residual spraying represent the cornerstones of malaria control programs. Resistance to chemistries used in these programs is now widespread and represents a significant threat to the gains seen in reducing malaria-related morbidity and mortality. Recently, disruption of the 20-hydroxyecdysone steroid hormone pathway was shown to reduce Plasmodium development and significantly reduce both longevity and egg production in a laboratory susceptible Anopheles gambiae population. Here, we demonstrate that disruption of this pathway by application of the dibenzoylhydrazine, methoxyfenozide (DBH-M), to insecticide resistant An. coluzzii, An. gambiae sl and An. funestus populations significantly reduces egg production in both topical and tarsal application. Moreover, DBH-M reduces adult longevity when applied topically, and tarsally after blood feeding. As the cytochrome p450s elevated in pyrethroid resistant Anopheles only bind DBH-M very weakly, this compound is unlikely to be subject to cross-resistance in a field-based setting. Manipulation of this hormonal signalling pathway therefore represents a potential complementary approach to current malaria control strategies, particularly in areas where high levels of insecticide resistance are compromising existing tools.

Item Type: Article
Subjects: QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ibmb.2020.103372
Depositing User: Samantha Sheldrake
Date Deposited: 08 Apr 2020 15:41
Last Modified: 09 Apr 2020 10:11
URI: https://archive.lstmed.ac.uk/id/eprint/14156

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