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Iron status of Burkinabé adolescent girls predicts malaria risk in the following rainy season

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Brabin, Loretta, Roberts, Stephen, Tinto, Halidou, Gies, Sabine, Diallo, Salou and Brabin, Bernard (2020) 'Iron status of Burkinabé adolescent girls predicts malaria risk in the following rainy season'. Nutrients, Vol 12, Issue 5, p. 1446.

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Abstract

High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were <20 years at baseline and 242 (22%) were pre-menarcheal. At baseline, prevalence of low body iron stores was 10%. At follow-up, 38% of adolescents had predominantly asymptomatic malaria parasitaemias, with no difference by menarcheal status. Higher body iron stores at baseline predicted an increased malaria risk in the following rainy season (OR 1.18 (95% CI 1.05, 1.34, p = 0.007) after adjusting for bed net use, age, menarche, and body mass index. We conclude that routine iron supplementation should not be recommended without prior effective malaria control.

Item Type: Article
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 155 Anemia
WS Pediatrics > Diseases of Children and Adolescents > General Diseases > WS 200 General works
WS Pediatrics > By Age Groups > WS 460 Adolescence (General)
Faculty: Department: Education
Digital Object Identifer (DOI): https://doi.org/10.3390/nu12051446
Depositing User: Stacy Murtagh
Date Deposited: 20 May 2020 11:56
Last Modified: 20 May 2020 11:56
URI: https://archive.lstmed.ac.uk/id/eprint/14441

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