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Structure, function, and regulation of thioesterases

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Swarbrick, Crystall, Nanson, Jeffrey D., Patterson, Ian ORCID: https://orcid.org/0000-0003-3465-0848 and Forwood, Jade K. (2020) 'Structure, function, and regulation of thioesterases'. Progress in Lipid Research, Vol 79, p. 101036.

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Abstract

Thioesterases are present in all living cells and perform a wide range of important biological functions by catalysing the cleavage of thioester bonds present in a diverse array of cellular substrates. Thioesterases are organised into 25 families based on their sequence conservation, tertiary and quaternary structure, active site configuration, and substrate specificity. Recent structural and functional characterisation of thioesterases has led to significant changes in our understanding of the regulatory mechanisms that govern enzyme activity and their respective cellular roles. The resulting dogma changes in thioesterase regulation include mechanistic insights into ATP and GDP-mediated regulation by oligomerisation, the role of new key regulatory regions, and new insights into a conserved quaternary structure within TE4 family members. Here we provide a current and comparative snapshot of our understanding of thioesterase structure, function, and regulation across the different thioesterase families.

Item Type: Article
Subjects: QU Biochemistry > Enzymes > QU 135 Enzymes
QU Biochemistry > Enzymes > QU 136 Hydrolases
QU Biochemistry > Carbohydrates. Lipids > QU 85 Lipids
Faculty: Department: Biological Sciences > Vector Biology Department
Digital Object Identifer (DOI): https://doi.org/10.1016/j.plipres.2020.101036
Depositing User: Mel Finley
Date Deposited: 22 May 2020 09:50
Last Modified: 12 Aug 2020 10:12
URI: https://archive.lstmed.ac.uk/id/eprint/14484

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