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Prolonged Fecal Shedding of SARS-CoV-2 in Pediatric Patients. A Quantitative Evidence Synthesis

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Santos, Victor Santana, Gurgel, Ricardo Quieroz, Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 and Martins-Filho, Paulo RIcardo (2020) 'Prolonged Fecal Shedding of SARS-CoV-2 in Pediatric Patients. A Quantitative Evidence Synthesis'. Journal of Pediatric Gastroenterology & Nutrition, Vol 71, Issue 2, pp. 150-152.

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Abstract

Objective: To investigate differences in viral shedding in respiratory and fecal samples from children with COVID-19.

Methods: We searched PubMed, SCOPUS, Embase and Web of Science databases to identify pediatric studies comparing the pattern of fecal and respiratory shedding of SARS-CoV-2 RNA. Summary estimates were calculated using random-effects models.

Results: Four studies reporting data from 36 children were included. A higher proportion of children had viral shedding in stools after 14 days of symptoms onset compared to respiratory samples (RR= 3.2, 95%CI 1.2 to 8.9, I2 = 51%). Viral RNA shedding was longer in fecal samples with a mean difference of approximately 9 days (Mean Difference = 8.6, 95%CI 1.7 to 15.4, I2 = 77%) compared with respiratory samples.

Conclusion: SARS-CoV-2 shedding seems to be present in feces for a longer time than in the respiratory tract of children. Although fecal SARS-CoV-2 presence in feces do not confirm its transmissibility, the high and fast spread of the COVID-19 disease worldwide indicate other transmission routes are also plausible.

Item Type: Article
Subjects: QY Clinical Pathology > Diagnostic Tests > QY 160 Feces
WA Public Health > WA 105 Epidemiology
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
WF Respiratory System > WF 100 General works
WS Pediatrics > WS 100 General works
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI): https://doi.org/10.1097/MPG.0000000000002798
Depositing User: Christine Bradbury
Date Deposited: 27 May 2020 10:31
Last Modified: 12 Aug 2020 10:18
URI: https://archive.lstmed.ac.uk/id/eprint/14485

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