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A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee

Claudianos, C., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, Johnson, R. M., Biswas, S., Schuler, M. A., Berenbaum, M. R., Feyereisen, R. and Oakeshott, J. G. (2006) 'A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee'. Insect Molecular Biology, Vol 15, Issue 5, pp. 615-636.

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Abstract

The honeybee genome has substantially fewer protein coding genes (approximate to 11 000 genes) than Drosophila melanogaster (approximate to 13 500) and Anopheles gambiae (approximate to 14 000). Some of the most marked differences occur in three superfamilies encoding xenobiotic detoxifying enzymes. Specifically there are only about half as many glutathione-S-transferases (GSTs), cytochrome P450 monooxygenases (P450s) and carboxyl/cholinesterases (CCEs) in the honeybee. This includes 10-fold or greater shortfalls in the numbers of Delta and Epsilon GSTs and CYP4 P450s, members of which clades have been recurrently associated with insecticide resistance in other species. These shortfalls may contribute to the sensitivity of the honeybee to insecticides. On the other hand there are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.

Item Type: Article
Uncontrolled Keywords: honeybee glutathione-s-transferase cytochrome p450 monooxygenase esterase insecticide resistance glutathione-s-transferase amino-acid substitution apis-mellifera l anisopteromalus-calandrae hymenoptera pyrethroid-resistant strain juvenile-hormone esterase moth mamestra-brassicae drosophila-melanogaster insecticide resistance anopheles-gambiae
Subjects: QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 565 Hymenoptera (Bees. Wasps. Ants)
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-2583.2006.00672.x
Depositing User: Sarah Lewis-Newton
Date Deposited: 21 Feb 2011 15:54
Last Modified: 06 Feb 2018 13:01
URI: http://archive.lstmed.ac.uk/id/eprint/1461

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