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A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease

Cooke, G. S., Tosh, K., Ramaley, P. A., Kaleebu, P., Zhuang, J., Nakiyingi, J. S., Watera, C., Gilks, C.F., French, Neil, Whitworth, J. A. G. and Hill, A. V. S. (2006) 'A polymorphism that reduces RANTES expression is associated with protection from death in HIV-seropositive Ugandans with advanced disease'. Journal of Infectious Disease, Vol 194, Issue 5, pp. 666-669.

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Abstract

We investigated the effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda. HIV-positive individuals homozygous for the INT1.1C polymorphism, which had been associated previously with low RANTES expression, were less likely to die than were those with other genotypes (hazard ratio, 0.53 [95% confidence interval, 0.33-0.83]; P = .007). This report of a non-human leukocyte antigen genetic association with HIV-1 and/or acquired immunodeficiency syndrome disease progression in an African population reveals a genetic effect different from that reported elsewhere for African Americans and may impact therapeutic strategies targeting the RANTES pathway in HIV infection.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QW Microbiology and Immunology > Immunity by Type > QW 541 Natural immunity. Immunogenetics
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.3 Etiology. Transmission
Digital Object Identifer (DOI): https://doi.org/10.1086/505875
Depositing User: Ms Julia Martin
Date Deposited: 22 Feb 2011 15:21
Last Modified: 07 Dec 2018 09:40
URI: http://archive.lstmed.ac.uk/id/eprint/1463

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