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Resisting resistance: dealing with the irrepressible problem of malaria

Edwards, Geoffrey and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2006) 'Resisting resistance: dealing with the irrepressible problem of malaria'. British Journal of Clinical Pharmacology, Vol 61, Issue 6, pp. 690-693.

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Abstract

The burgeoning problem of malaria in the developing world and the relentless march of drug resistance demand that we continue to seek new chemotherapeutic strategies. Given the enormous expense of developing and marketing new chemical entities, we often rely on an increased understanding of the pharmacology of older drugs and judicious use of drug combinations. Development is being driven primarily by public-private partnerships from academic investigations. Two such agents are the antifolate combination Lapdap (TM), already licensed and soon to be combined with artesunate, and isoquine, a novel isoquinoline, about to enter clinical trials. Other drug combinations designed to minimize the spread of resistance are in the pipeline. Such developments are crucial as it becomes clear that existing drugs, even those used in combinations, may have limited lifetimes.

Item Type: Article
Uncontrolled Keywords: malaria drug resistance lapdap dapsone chlorproguanil artesunate isoquine plasmodium-falciparum malaria elimination half-life in-vivo artemether-lumefantrine benflumetol coartem
Subjects: QV Pharmacology > QV 38 Drug action.
QV Pharmacology > QV 4 General works
QV Pharmacology > QV 55 Pharmaceutical preparations (General)
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QV Pharmacology > Pharmaceutical Processes. Packaging. Labeling > QV 778 Pharmaceutical processes
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-2125.2006.02674x
Depositing User: Sarah Lewis-Newton
Date Deposited: 15 Apr 2011 11:22
Last Modified: 06 Feb 2018 13:01
URI: http://archive.lstmed.ac.uk/id/eprint/1480

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