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Pyrethroid insecticide resistance and treated bednets efficacy in malaria control

Enayati, Ahmad Ali and Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 (2006) 'Pyrethroid insecticide resistance and treated bednets efficacy in malaria control'. Pesticide Biochemistry and Physiology, Vol 84, Issue 2, pp. 116-126.

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Abstract

Most of the studies on insecticide impregnated bednets efficacy in malaria control have been undertaken in areas where mosquitoes are pyrethroid susceptible. The efficacy of pyrethroid-treated bednets was not compromised even when mosquitoes were kdr resistant. Here, we evaluate a case in which mosquitoes have kdr-like pyrethroid resistance coupled with metabolic mechanisms. Metabolic and kdr-resistance mechanisms in Anopheles stephensi were characterised in our previous study and this easily colonised species was used as a model to examine the efficacy of pyrethroid-treated bednets in the laboratory. Bioassays performed on adults of susceptible (Beech) and resistant (DUB-S) strains using WHO 0.75% permethrin-impregnated papers showed a resistance ratio of 9.75. The recovery rate of the mosquitoes of the DUB-S strain was significantly higher than that of the susceptible strain Beech. The overall permethrin metabolism rates by DUB-S, measured by HPLC method, were 1.5-fold more than by Beech strain. Bioassays performed on DUB-S mosquitoes using different pyrethroid-treated bednets showed that only deltamethrin at 25 mg/m(2) and alpha-cypermethrin at 40 mg/m(2) produced adequate mortality rates. Four other pyrethroids, including permethrin, were ineffective. The deterrency test performed on susceptible and resistant An. stephensi showed that there are significant differences between the entry rates of susceptible and resistant mosquitoes into the exposure tube containing permethrin-treated bednet. These data show that when mosquitoes have both kdr-type and metabolic resistance mechanisms, the efficacy of pyrethroid-treated bednets is questionable. (c) 2005 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: itn efficacy pyrethroids resistance malaria permethrin-impregnated bednets mosquito anopheles-stephensi experimental hut trials colorado potato beetle bed nets targeted chemoprophylaxis west-africa rural area culex-quinquefasciatus cost-effectiveness
Subjects: QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
WA Public Health > Preventive Medicine > WA 108 Preventive health services. Preventive medicine. Travel Medicine.
WA Public Health > Preventive Medicine > WA 110 Prevention and control of communicable diseases. Transmission of infectious diseases
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pestbp.2005.06.001
Depositing User: Sarah Lewis-Newton
Date Deposited: 24 Feb 2011 15:44
Last Modified: 06 Feb 2018 13:01
URI: http://archive.lstmed.ac.uk/id/eprint/1482

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