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Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study

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Kamtchum-Tatuene, Joseph, Kachingwe, Gloria Mwangalika, Mwandumba, Henry ORCID: https://orcid.org/0000-0003-4470-3608, Solomon, Tom and Benjamin, Laura A. (2020) 'Endothelial dysfunction and carotid atherosclerosis in Malawian adults: A cross-sectional study'. eNeurologicalSci, Vol 20, p. 100252.

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Abstract

Background and objective
In sub-Saharan Africa, data on prevalence, risk factors and pathobiology of carotid atherosclerosis are scarce. We aimed to investigate the relationship between biomarkers of endothelial dysfunction and carotid atherosclerosis.

Methods
Carotid ultrasound was performed in 66 patients. Plasma concentration of ICAM-1, PAI-1, VEGF, and soluble thrombomodulin were measured by ELISA. A univariable logistic regression analysis was performed to study the relationship between carotid atherosclerosis, biomarkers of endothelial dysfunction, and various demographic and clinical parameters of the participants.

Results
The mean age of the participants was 58.7 years (95% CI: 54.4–63.1). Carotid atherosclerosis was diagnosed in 39.4% (95% CI: 27.6–52.2). In the univariable logistic regression, the following factors were associated with carotid atherosclerosis: age > 45 years (OR = 12.0, 95% CI: 1.4–98.8, p = .02), hypertension (OR = 3.8, 95% CI: 1.2–12.1, p = .02), and high-level of soluble thrombomodulin (OR = 3.4, 95% CI: 1.2–10.0, p = .02).

Conclusions
There is an association between high levels of soluble thrombomodulin and carotid atherosclerosis in Malawian adults. Further studies with a larger sample size are needed to confirm our findings in other African populations.

Item Type: Article
Subjects: QS Anatomy > Histology > QS 532.5 Specific types of tissue
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WG Cardiovascular System > Heart. Heart Diseases > WG 200 General works
Faculty: Department: Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ensci.2020.100252
SWORD Depositor: JISC Pubrouter
Depositing User: JISC Pubrouter
Date Deposited: 01 Jul 2020 09:23
Last Modified: 03 Aug 2020 10:27
URI: https://archive.lstmed.ac.uk/id/eprint/14906

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