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Complex dynamics and stability of resistance to antimalarial drugs

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Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X (2006) 'Complex dynamics and stability of resistance to antimalarial drugs'. Parasitology, Vol 132, pp. 615-624.

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Abstract

A succession of antimalarial drugs has been deployed to treat human falciparum malaria but each has, in turn, been nullified by the spread of drug resistance. The consensus view has always been that, once present, resistance will inevitably rapidly increase to 100%. However, recent field evidence has shown this is not inevitable, and that drug resistance may initially spread and then stabilize at relatively low frequencies. It is proposed that intense competition between separate malaria clones co-infecting the same human can generate complex dynamics capable of explaining this observation. Standard Population genetic analysis confirms this assertion. The dynamics underlying the evolution of antimalarial resistance may therefore be much more complex than previously realized, and can resolve the apparent paradox between field data and the underlying theory of the evolution of resistance. This explanation is novel and the results are equally applicable to other parasitic species where multiple infections of the same host are common.

Item Type: Article
Uncontrolled Keywords: plasmodium falciparum drug resistance dynamics competition fitness uncomplicated falciparum-malaria plasmodium-falciparum sulfadoxine-pyrimethamine dihydrofolate-reductase chloroquine use spread model transmission evolution parasite
Subjects: QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 700 Protozoan infections (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1017/S0031182005009790
Depositing User: Martin Chapman
Date Deposited: 10 May 2011 17:04
Last Modified: 19 Sep 2019 11:29
URI: https://archive.lstmed.ac.uk/id/eprint/1498

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