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The cytochrome bc1 complex as an antipathogenic target

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Fisher, Nicholas, Meunier, Brigitte and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2020) 'The cytochrome bc1 complex as an antipathogenic target'. Febs Letters. (In Press)

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Abstract

The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochrome bc1, and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.

Item Type: Article
Subjects: QU Biochemistry > Cells and Genetics > QU 300 General works
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 252 Antifungal agents. Antifungal antibiotics
QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 269 Antineoplastic agents. Antineoplastic antibiotics
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 190 Hemoglobin and other hemeproteins. Porphyrins (Associated with hemoglobin)
Faculty: Department: Biological Sciences > Department of Tropical Disease Biology
Digital Object Identifer (DOI): https://doi.org/10.1002/1873-3468.13868
Depositing User: Cathy Waldron
Date Deposited: 14 Jul 2020 11:55
Last Modified: 03 Aug 2020 10:37
URI: https://archive.lstmed.ac.uk/id/eprint/15036

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