LSTM Home > LSTM Research > LSTM Online Archive

Implementation of Antibody Rapid Diagnostic Testing versus Real-Time Reverse Transcription-PCR Sample Pooling in the Screening of COVID-19: a Case of Different Testing Strategies in Africa

Downloads

Downloads per month over past year

Nyazika, Tinashe, Kaela, Rabelani, Mugoni, Mathias, Musomekwa, Kudakwashe, Kyei-Baafour, Eric, Chiwanda, Simbarashe, Mapondera, Prichard T., Makawa, Tatenda, Sithole, Elliot M, Mavunganidze, George, Manasa, Justen, Jambo, Kondwani ORCID: https://orcid.org/0000-0002-3195-2210 and Musarurwa, Cuthbert (2020) 'Implementation of Antibody Rapid Diagnostic Testing versus Real-Time Reverse Transcription-PCR Sample Pooling in the Screening of COVID-19: a Case of Different Testing Strategies in Africa'. mSphere, Vol 5, Issue 4, e00524-20.

[img]
Preview
Text
Nyazika mSphere.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (796kB) | Preview
[img]
Preview
Text
mSphere-2020-Nyazika-e00524-20.full.pdf - Published Version
Available under License Creative Commons Attribution.

Download (292kB) | Preview

Abstract

COVID-19 has wreaked havoc across the globe, although cases in Africa remain lower than 50 other regions but they are gradually on an upward trajectory. To date, COVID-19 cases have 51 been reported in 54 countries. However, due to limited SARS-COV-2 rRT-PCR testing 52 capacity and scarcity of testing reagents, it is probable that the total number of cases could 53 far exceed published statistics. In this viewpoint, using Ghana, Malawi, South Africa and 54 Zimbabwe as examples of countries that have implemented different testing strategies, we 55 argue that the implementation of sample pooling for rRT-PCR over antibody rapid diagnostic 56 testing could have a greater impact in assessing disease burden. Sample pooling offers huge 57 advantages compared to single test rRT-PCR, as it lowers experimental costs, personnel 58 time, reduces burnout and analytical run-times. Africa is already strained in terms of testing 59 resources for COVID-19, hence cheaper alternative ways need to be implemented to 60 conserve resources, maximise on mass testing and reduce transmission in the wider 61 population.

Item Type: Article
Subjects: WA Public Health > WA 105 Epidemiology
WA Public Health > Preventive Medicine > WA 243 Diagnositic services
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 505 Viral respiratory tract infections
Faculty: Department: Clinical Sciences & International Health > Clinical Sciences Department
Clinical Sciences & International Health > Malawi-Liverpool-Wellcome Programme (MLW)
Digital Object Identifer (DOI): https://doi.org/10.1128/mSphere.00524-20
Depositing User: Stacy Murtagh
Date Deposited: 10 Aug 2020 14:49
Last Modified: 10 Aug 2020 14:49
URI: https://archive.lstmed.ac.uk/id/eprint/15130

Statistics

View details

Actions (login required)

Edit Item Edit Item