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Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria

Montgomery, Jacqui, Milner, D. A., Tse, M. T., Njobvu, A., Kayira, K., Dzamalala, C. P., Taylor, T. E., Rogerson, S. J., Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 and Molyneux, Malcolm E (2006) 'Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria'. Journal of Infectious Disease, Vol 194, Issue 1, pp. 115-122.

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Abstract

Falciparum malaria is characterized by cytoadherence of host erythrocytes containing mature asexual-stage parasites and the consequent sequestration of these forms in tissue microvasculature. A postmortem study of pediatric malaria provided us with the opportunity to compare the genetic complexity of circulating and sequestered Plasmodium falciparum populations, in patients with fatal cerebral malaria ( CM) versus control subjects with incidental P. falciparum parasitemia who died of causes other than malaria. Parasite genotypes identified in peripheral blood collected at the time of admission to the hospital constituted a subset of those detected in the tissues at death. Despite a higher tissue burden of parasitized erythrocytes in patients with CM than in parasitemic control subjects, parasite populations in tissues from patients with CM were less genetically complex, and the genotypes were more homogeneously distributed throughout the body, than in patients with incidental infection. Our findings support the notion that CM is associated with the emergence of a small number of dominant genotypes in an infected individual.

Item Type: Article
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 755.1 General coverage
WS Pediatrics > By Age Groups > WS 430 Infancy
WS Pediatrics > By Age Groups > WS 440 Preschool child
Digital Object Identifer (DOI): https://doi.org/10.1086/504689
Depositing User: Ms Julia Martin
Date Deposited: 04 Mar 2011 12:41
Last Modified: 07 Dec 2018 10:19
URI: http://archive.lstmed.ac.uk/id/eprint/1558

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