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Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Newton, P. N., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Angus, B. J., Chierakul, W., Dondorp, A., Ruangveerayuth, R., Silamut, K., Teerapong, P., Suputtamongkol, Y., Looareesuwan, S. and White, N. J. (2006) 'Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 100, Issue 2, pp. 184-186.

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Abstract

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: malaria plasmodium falciparum quinine pharmacokinetics treatment failure thailand uncomplicated falciparum-malaria plasmodium-falciparum pharmacokinetics resistance thailand
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QV Pharmacology > QV 38 Drug action.
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.trstmh.2005.01.008
Depositing User: Martin Chapman
Date Deposited: 15 Mar 2011 14:46
Last Modified: 06 Feb 2018 13:02
URI: http://archive.lstmed.ac.uk/id/eprint/1561

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