LSTM Home > LSTM Research > LSTM Online Archive

Grey nails predict low CD4 cell count among untreated patients with HIV infection in Malawi

Scarborough, M., Gordon, Stephen, French, Neil, Phiri, C., Musaya, J. and Zijlstra, E. E. (2006) 'Grey nails predict low CD4 cell count among untreated patients with HIV infection in Malawi'. AIDS, Vol 20, Issue 10, pp. 1415-1417.

Full text not available from this repository.

Abstract

Background: Alternative criteria for initiating antiretroviral therapy to CD4 testing or clinical illness are needed in Malawi.
Method: We tested if grey nails could be used to identify patients with a CD4 cell count less than 200 cells/mu l who had not yet presented with AIDS-defining illnesses.
Results: Using a set of 242 photographs we showed good inter-observer agreement for grey nails (kappa = 0.66; P < 0.0001) and the positive predictive value of grey nails for a CD4 cell count of less than 200 cells/mu l was 81% (chi(2) < 0.0001).
Conclusions: Grey nails have been associated with HIV infection and we have shown significant correlation of this sign with a low CD4 cell count. For clinicians working in sub-Saharan Africa without access to CD4 cell count testing, grey or DB nails represent an additional staging sign to help identify a sub-group of patients likely to benefit from ART. (c) 2006 Lippincott Williams & Wilkins.

Item Type: Article
Uncontrolled Keywords: clinical staging nails hiv-1 aids anti-retroviral therapy
Subjects: WB Practice of Medicine > Diagnosis > General Diagnosis > WB 143 Signs and symptoms
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 200 Physical diagnosis (General)
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.1 Diagnosis
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.2 Therapy
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.41 General coverage
Digital Object Identifer (DOI): https://doi.org/10.1097/01.aids.0000233575.26349.cc
Depositing User: Sarah Lewis-Newton
Date Deposited: 07 Mar 2011 16:09
Last Modified: 22 Jun 2018 09:21
URI: http://archive.lstmed.ac.uk/id/eprint/1588

Statistics

View details

Actions (login required)

Edit Item Edit Item