Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users

Gertz, Alida M, Bishop, Ian J, Boikhutso, Simon, Lechiile, Kwana, Badubi, Opelo, Mussa, Aamirah, Westhoff, Carolyn L and Morroni, Chelsea ORCID: https://orcid.org/0000-0002-2026-6039 (2020) 'Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users'. Contraception, Vol 102, Issue 6, pp. 403-405.

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Abstract

Objective
To compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm.
Study design
Sub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples.
Results
Plasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland–Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: −4.1, 15.9 pg/mL).
Conclusions
We found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm.
Implications
Our data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.

Item Type:	Article
Uncontrolled Keywords:	Contraceptive implant; etonogestrel; pharmacokinetics; ipsilateral arm; contralateral arm
Subjects:	WA Public Health > Health Problems of Special Population Groups > WA 309 Women's health WP Gynecology > Contraception > WP 630 Contraception WP Gynecology > Contraception > WP 640 Contraceptive devices (General and female)
Faculty: Department:	Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.contraception.2020.08.011
Depositing User:	Tina Bowers
Date Deposited:	05 Nov 2020 11:31
Last Modified:	26 Aug 2021 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/16012

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