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A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection

Turner, Joseph, Mand, S., Debrah, A. Y., Muehlfeld, J., Pfarr, K., McGarry, Helen F., Adjei, O., Taylor, Mark and Hoerauf, A. (2006) 'A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection'. Clinical Infectious Diseases, Vol 42, Issue 8, pp. 1081-1089.

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Abstract

Background. Eight- and 6-week courses of doxycycline are superior to standard treatment of bancroftian filariasis. Standard treatment ( albendazole plus ivermectin) is associated with adverse reactions. We assessed whether a shorter (i.e, 3-week) course of doxycycline with standard treatment would show superior efficacy to standard treatment alone and reduce the incidence of adverse reactions.
Methods. A total of 44 adults from Ghana were recruited in January 2003: 20 received doxycycline ( 200 mg/day) for 3 weeks, and 24 received matching placebo. Participants received albendazole ( 400 mg) and ivermectin (150 mg/kg) at month 4, and adverse reactions were assessed 48 h later. Treatment efficacy was evaluated at months 4, 12, and 24.
Results. The microfilariae level was significantly reduced after receipt of doxycycline treatment at months 4 (P = .017), 12 (P = .001), and 24 (P = .041). The microfilariae level was only significantly reduced at month 12 in the placebo group (P = .041). At all follow-up points, the microfilariae level was significantly lower in the doxycycline group. Adverse reactions to standard antifilarial treatment were similar in frequency between the doxycycline group (in 7 of 11 subjects) and the placebo group (in 13 of 17 subjects). Moderate reactions only occurred in the placebo group (in 3 of 17 subjects). Severity of adverse reaction was associated with microfilaremia (P = .037), Wolbachia bacteria in plasma (P = .048), and proinflammatory cytokines in plasma (P = .048). Adult Pp. 037 Pp. 048 Pp. 019 parasite viability was not significantly different between doxycycline and placebo groups at months 12 or 24.
Conclusions. Treatment with doxycycline for 3 weeks is more effective in inducing a long-term amicrofilaremia than is standard treatment alone, but it is ineffective at inducing curative effects. Inflammatory reactions to antifilarial treatment are associated with levels of microfilariae and Wolbachia endosymbionts released into plasma.

Item Type: Article
Uncontrolled Keywords: lymphatic filariasis bacterial endosymbionts wolbachia endosymbionts onchocerca-volvulus adverse-reactions diethylcarbamazine pathogenesis efficacy interleukin-6 chemotherapy
Subjects: QV Pharmacology > QV 38 Drug action.
QV Pharmacology > QV 4 General works
QV Pharmacology > Toxicology > General Toxicology > QV 600 General works
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QX Parasitology > Helminths. Annelida > QX 203 Nematoda
WB Practice of Medicine > Therapeutics > WB 330 Drug therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
Digital Object Identifer (DOI): https://doi.org/10.1086/501351
Depositing User: Sarah Lewis-Newton
Date Deposited: 25 Jul 2011 14:30
Last Modified: 15 Jun 2018 14:49
URI: http://archive.lstmed.ac.uk/id/eprint/1619

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