Tools
Tools
Hadlett, Max, Nagi, Sanjay, Sarkar, Manas, Paine, Mark 
ORCID: https://orcid.org/0000-0003-2061-7713 and Weetman, David ORCID: https://orcid.org/0000-0002-5820-1388
(2021)
'High concentrations of membrane fed ivermectin are required for substantial lethal and sublethal impacts on Aedes aegypti'. Parasites & Vectors, Vol 14, Issue 9.
|
Text
s13071-020-04512-5.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background
With widespread insecticide resistance in mosquito vectors, there is a pressing need to evaluate alternatives with different modes of action. Blood containing the antihelminthic drug ivermectin has been shown to have lethal and sub-lethal effects on mosquitoes. Almost all work to date has been on Anopheles spp., but impacts on other anthropophagic vectors could provide new options for their control, or additional value to anti-malarial ivermectin programmes.
Methods
Using dose-response assays delivered by membrane feeding, we evaluated the effects of ivermectin on daily mortality (up to 14-days post blood-feed) and fecundity of an Indian strain of Aedes aegypti.
Results
The 7-day LC50 of ivermectin was calculated to be 178.6 ng/ml (95% CIs 142.3 – 218.4), much higher than recorded in all previous studies of Anopheles spp. In addition, significant effects on fecundity and egg hatch rates were only recorded at high ivermectin concentrations (≥ 250 ng/ul).
Conclusion
Our results suggest that levels present in human blood with current dosing regimes from mass drug administration or even a recent higher-dose antimalaria trial are unlikely to have a substantial impact on Ae. aegypti. Moreover, owing to the strong anthropophagy of Ae. aegypti, delivery of higher levels in livestock blood is also unlikely to be an effective option. However, other potential toxic impacts from ivermectin metabolites, accumulation in tissues, sublethal effects on behaviour, or antiviral action might increase the efficacy of ivermectin against Ae. aegypti and the arboviral diseases it transmits, and require further
investigation.
| Item Type: | Article |
|---|---|
| Subjects: | QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes QX Parasitology > Insects. Other Parasites > QX 525 Aedes |
| Faculty: Department: | Biological Sciences > Vector Biology Department |
| Digital Object Identifer (DOI): | https://doi.org/10.1186/s13071-020-04512-5 |
| Depositing User: | Luciene Salas Jennings |
| Date Deposited: | 12 Jan 2021 11:07 |
| Last Modified: | 12 Jan 2021 11:07 |
| URI: | https://archive.lstmed.ac.uk/id/eprint/16455 |
Statistics
Actions (login required)
 |
Edit Item |