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IgM, Fc mu Rs, and malarial immune evasion.

Czajkowsky, Daniel M, Salanti, Ali, Ditlev, Sisse B, Shao, Zhifeng, Ghumra, Ashfaq, Rowe, J Alexandra and Pleass, Richard ORCID: https://orcid.org/0000-0001-7438-8296 (2010) 'IgM, Fc mu Rs, and malarial immune evasion.'. Journal of immunology (Baltimore, Md. : 1950), Vol 184, Issue 9, pp. 4597-603.

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Abstract

IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered Fc mu R localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

Item Type: Article
Uncontrolled Keywords: I mmunoglobulin M; Malaria; Immunity
Subjects: QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.4049/jimmunol.1000203
Depositing User: Mary Creegan
Date Deposited: 01 Feb 2011 11:32
Last Modified: 06 Feb 2018 13:02
URI: https://archive.lstmed.ac.uk/id/eprint/1694

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