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Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

Calis, Job C J, Phiri, Kamija S, Vet, Raymond J W M, de Haan, Rob J, Munthali, Francis, Kraaijenhagen, Robert J, Hulshof, Paul J M, Molyneux, Malcolm E, Brabin, Bernard, Boele van Hensbroek, Michael and Bates, Imelda ORCID: https://orcid.org/0000-0002-0862-8199 (2010) 'Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.'. AIDS, Vol 24, Issue 18, pp. 2883-7.

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Abstract

Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.

Item Type: Article
Subjects: WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
WH Hemic and Lymphatic Systems > Hematologic Diseases. Immunologic Factors. Blood Banks > WH 150 Erythrocytes
WS Pediatrics > Diseases of Children and Adolescents > By System > WS 300 Hemic and lymphatic system
Digital Object Identifer (DOI): https://doi.org/10.1097/QAD.0b013e32833fed27
Depositing User: Tina Bowers
Date Deposited: 15 Dec 2010 10:39
Last Modified: 22 Oct 2019 08:21
URI: https://archive.lstmed.ac.uk/id/eprint/1705

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