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Seroepidemiology and risk factors of hepatitis B virus in Aden, Yemen

Bawazir, Amen Ahmed, Parry, Christopher M, Hart, C. Anthony, Sallam, Tallal A, Beeching, Nicholas ORCID: https://orcid.org/0000-0002-7019-8791 and Cuevas, Luis ORCID: https://orcid.org/0000-0002-6581-0587 (2011) 'Seroepidemiology and risk factors of hepatitis B virus in Aden, Yemen'. Journal of Infection and Public Health, Vol 4, pp. 48-54.

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Abstract

Background
There is little published data concerning hepatitis B virus (HBV) infection in Aden and no data concerning risk factors for infection. This study aimed to determine the prevalence of HBV infection and risk factors for infection in Aden, Yemen.
Methods
A prospective cross sectional survey of individuals attending primary health care facilities was stratified by age and population size. Five hundred and thirty five participants were interviewed and serum was screened for the presence of Immunoglobin G HBV core antibodies (antiHBc). AntiHBc positive participants were tested for antibodies to hepatitis B surface antigen (HBsAg). A case–control analysis of risk factors for HBV was undertaken comparing risk factors between antiHBc positive cases and seronegative controls.
Results
The age-standardized seroprevalence for antiHBc was 16.2% (95% confidence interval (CI) 13.1–19.3) and for HBsAg was 1.5% (95% CI 0.5–2.5). The seroprevalence of antiHBc and HBsAg was estimated to range from 5.5% and 0% in infants to 40% and 4.6% in adults, respectively (p < 0.001). Age (AOR = 1.03, 95% CI = 1.01–1.05), household size (>5–9 members, AOR = 2.9, 95% CI = 1.1–7.6) and ownership of a landline telephone (AOR = 2.8, 95% CI = 1.3–5.8) were independent risk factors for HBV infection.
Conclusions
HBV is still a public health problem in this community, with older individuals having much higher prevalence than younger generations. The results of this study would categorise Aden as a low HBV endemic zone. Perinatal transmission does not seem to be a major route of transmission

Item Type: Article
Uncontrolled Keywords: hepatitis B virus; Seroepidemiology; Risk factors; Aden; Yemen
Subjects: WC Communicable Diseases > Virus Diseases > Viral Hemorrhagic Fevers. Other Virus Diseases > WC 536 Human viral hepatitis
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Groups (2002 - 2012) > Clinical Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.jiph.2010.11.003
Depositing User: Users 43 not found.
Date Deposited: 25 Mar 2011 10:42
Last Modified: 06 Feb 2018 13:02
URI: http://archive.lstmed.ac.uk/id/eprint/1782

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