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The role of ICAM-1 in Plasmodium falciparum cytoadherence

Chakravorty, S. and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2005) 'The role of ICAM-1 in Plasmodium falciparum cytoadherence'. European Journal of Cell Biology, Vol 84, Issue 1, pp. 15-27.

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Abstract

Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1) and its role in mediating the interaction between the parasitised red blood cell (PRBC) and the vascular endothelium. We highlight the nature of the interaction between ICAM-1 and the parasite-expressed PfEMP-1 molecule at the molecular level. The review also discusses the complexity of the PRBC-endothelial cell interaction band the mechanisms that underlie parasite cytoadherence. (C) 2004 Elsevier GmbH. All rights reserved.

Item Type: Article
Uncontrolled Keywords: intercellular adhesion molecule-1 (icam-1) endothelial cell plasmodium falciparum adhesion intercellular-adhesion molecule-1 microvascular endothelial-cells murine cerebral malaria chondroitin sulfate-a n-terminal domain red-blood-cells infected erythrocytes parasitized erythrocytes mediates cytoadherence antigenic variation
Subjects: QX Parasitology > Protozoa > QX 135 Plasmodia
QZ Pathology > Manifestations of Disease > QZ 140 General manifestations of disease
QZ Pathology > Manifestations of Disease > QZ 140 General manifestations of disease > QZ 150 Local reactions to injury and disease
WB Practice of Medicine > Diagnosis > General Diagnosis > WB 143 Signs and symptoms
WB Practice of Medicine > Medical Climatology > WB 710 Diseases of geographic areas
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ejcb.2004.09.002
Depositing User: Sarah Lewis-Newton
Date Deposited: 29 Sep 2011 15:28
Last Modified: 06 Feb 2018 13:02
URI: http://archive.lstmed.ac.uk/id/eprint/1885

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