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Insect glutathione transferases and insecticide resistance

Enayati, Ahmad Ali, Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247 and Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173 (2005) 'Insect glutathione transferases and insecticide resistance'. Insect Molecular Biology, Vol 14, Issue 1, pp. 3-8.

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Abstract

Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in aerobic organisms. They play a central role in the detoxification of both endogenous and xenobiotic compounds and are also involved in intracellular transport, biosynthesis of hormones and protection against oxidative stress. Interest in insect GSTs has primarily focused on their role in insecticide resistance. GSTs can metabolize insecticides by facilitating their reductive dehydrochlorination or by conjugation reactions with reduced glutathione, to produce water-soluble metabolites that are more readily excreted. In addition, they contribute to the removal of toxic oxygen free radical species produced through the action of pesticides. Annotation of the Anopheles gambiae and Drosophila melanogaster genomes has revealed the full extent of this enzyme family in insects. This mini review describes the insect GST enzyme family, focusing specifically on their role in conferring insecticide resistance.

Item Type: Article
Additional Information: The definitive version is available at www3.interscience.wiley.com
Uncontrolled Keywords: insects insecticide resistance detoxification glutathione transferases housefly musca-domestica vector anopheles-gambiae s-transferase drosophila-melanogaster molecular-cloning heterologous expression aedes-aegypti nilaparvata-lugens catalytic function supergene family
Subjects: QU Biochemistry > Enzymes > QU 135 Enzymes
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 525 Aedes
QX Parasitology > Insects. Other Parasites > QX 600 Insect control. Tick control
WA Public Health > Preventive Medicine > WA 240 Disinfection. Disinfestation. Pesticides (including diseases caused by)
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-2583.2004.00529.x
Depositing User: Martin Chapman
Date Deposited: 06 Sep 2011 10:52
Last Modified: 06 Feb 2018 13:02
URI: http://archive.lstmed.ac.uk/id/eprint/1900

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