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Quinolines and artemisinin: Chemistry, biology and history

Bray, Patrick, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, P. M (2005) 'Quinolines and artemisinin: Chemistry, biology and history'. Current Topics in Microbiology and Immunology, Vol 295, pp. 3-38.

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Abstract

Plasmodium falciparum is the most important parasitic pathogen in humans, causing hundreds of millions of malaria infections and millions of deaths each year. At present there is no effective malaria vaccine and malaria therapy is totally reliant on the use of drugs. New drugs are urgently needed because of the rapid evolution and spread of parasite resistance to the current therapies. Drug resistance is one of the major factors contributing to the resurgence of malaria, especially resistance to the most affordable drugs such as chloroquine. We need to fully understand the antimalarial mode of action of the existing drugs and the way that the parasite becomes resistant to them in order to design and develop the new therapies that are so urgently needed. In respect of the quinolines and artemisinins, great progress has been made recently in studying the mechanisms of drug action and drug resistance in malaria parasites. Here we summarize from a historical, biological and chemical, perspective the exciting new advances that have been made in the study of these important antimalarial drugs.

Item Type: Article
Additional Information: From special issue entitled "Malaria: Drugs, Disease and Post-genomic Biology" 10.1007/3-540-29088-5
Uncontrolled Keywords: antimalarial-drug artemisinin human malaria parasites falciparum-infected erythrocytes resistant plasmodium-falciparum nuclear magnetic-resonance spin-trapping evidence mechanism-based design chloroquine-resistance in-vitro qinghaosu artemisinin
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QW Microbiology and Immunology > Immune Responses > QW 700 Infection. Mechanisms of infection and resistance.
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 805 Vaccines. Antitoxins. Toxoids
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 750 Malaria
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1007/3-540-29088-5_1
Depositing User: Sarah Lewis-Newton
Date Deposited: 05 Oct 2011 16:41
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/1940

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