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Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

Bray, Patrick, Martin, R. E., Tilley, L., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Kirk, K. and Fidock, D. A. (2005) 'Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance'. Molecular Microbiology, Vol 56, Issue 2, pp. 323-333.

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Abstract

Recent studies have highlighted the importance of a parasite protein referred to as the chloroquine resistance transporter (PfCRT) in the molecular basis of Plasmodium falciparum resistance to the quinoline antimalarials. PfCRT, an integral membrane protein with 10 predicted transmembrane domains, is a member of the drug/metabolite transporter superfamily and is located on the membrane of the intra-erythrocytic parasite's digestive vacuole. Specific polymorphisms in PfCRT are tightly correlated with chloroquine resistance. Transfection studies have now proven that pfcrt mutations confer verapamil-reversible chloroquine resistance in vitro and reveal their important role in resistance to quinine. Available evidence is consistent with the view that PfCRT functions as a transporter directly mediating the efflux of chloroquine from the digestive vacuole.

Item Type: Article
Uncontrolled Keywords: drug/metabolite transporter superfamily digestive vacuolar ph acridine-orange fluorescence transmembrane protein pfcrt drug-resistance infected erythrocytes malaria parasites in-vitro halofantrine resistance ferriprotoporphyrin-ix
Subjects: QV Pharmacology > QV 38 Drug action.
QW Microbiology and Immunology > QW 45 Microbial drug resistance. General or not elsewhere classified.
QX Parasitology > Protozoa > QX 135 Plasmodia
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-2958.2005.04556.x
Depositing User: Sarah Lewis-Newton
Date Deposited: 14 Oct 2011 15:00
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/1944

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