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Wolbachia variability and host effects on crossing type in Culex mosquitoes [Letter]

Sinkins, Steven P., Walker, Thomas, Lynd, Amy, Steven, Andrew, Makepeace, Benjamin L., Godfray, H. C. J. and Parkhill, J. (2005) 'Wolbachia variability and host effects on crossing type in Culex mosquitoes [Letter]'. Nature, Vol 436, Issue 7048, pp. 257-260.

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Abstract

Wolbachia is a common maternally inherited bacterial symbiont able to induce crossing sterilities known as cytoplasmic incompatibility (CI) in insects(1,2). Wolbachia-modified sperm are unable to complete fertilization of uninfected ova, but a rescue function allows infected eggs to develop normally. By providing a reproductive advantage to infected females, Wolbachia can rapidly invade uninfected populations(3), and this could provide a mechanism for driving transgenes through pest populations(4,5). CI can also occur between Wolbachia-infected populations and is usually associated with the presence of different Wolbachia strains(1). In the Culex pipiens mosquito group ( including the filariasis vector C. quinquefasciatus) a very unusual degree of complexity of Wolbachia-induced crossing-types has been reported, with partial or complete CI that can be unidirectional or bidirectional(6-11), yet no Wolbachia strain variation was found(11). Here we show variation between incompatible Culex strains in two Wolbachia ankyrin repeat-encoding genes associated with a prophage region, one of which is sex-specifically expressed in some strains, and also a direct effect of the host nuclear genome on CI rescue.

Item Type: Article
Uncontrolled Keywords: cytoplasmic incompatibility bacteriophage-wo pipiens l populations drosophila transmission endosymbiont arthropods resistance evolution
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Helminths. Annelida > QX 203 Nematoda
Faculty: Department: Groups (2002 - 2012) > Vector Group
Groups (2002 - 2012) > Veterinary Parasitology Group (2002-2008)
Digital Object Identifer (DOI): https://doi.org/10.1038/nature03629
Depositing User: Ms Julia Martin
Date Deposited: 01 Dec 2011 14:12
Last Modified: 06 Feb 2018 13:03
URI: https://archive.lstmed.ac.uk/id/eprint/1945

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