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Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy

Nzila, Alexis, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Marsh, Kevin, Sims, P. F. G. and Hyde, J. E. (2005) 'Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy'. Trends in Parasitology, Vol 21, Issue 6, pp. 292-298.

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Abstract

New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we focus on folate enzymes used clinically as anticancer drug targets, in addition to those that have potential to be used as drug targets, for which there are inhibitors at various stages of development. We discuss how this information could lead to the identification of new targets in malaria parasites.

Item Type: Article
Uncontrolled Keywords: reductase-thymidylate synthase falciparum dihydrofolate-reductase dependent methionine synthase genes encoding enzymes plasmodium-falciparum methenyltetrahydrofolate cyclohydrolase methylenetetrahydrofolate dehydrogenase serine hydroxymethyltransferase folylpolyglutamate synthetase functional expression
Subjects: QV Pharmacology > Anti-Inflammatory Agents. Anti-Infective Agents. Antineoplastic Agents > QV 256 Antimalarials
QX Parasitology > Protozoa > QX 135 Plasmodia
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 770 Therapy
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.pt.2005.04.002
Depositing User: Ms Julia Martin
Date Deposited: 14 Dec 2011 16:51
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/1975

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