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Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia

Kyelem, D., Medlock, J., Sanou, S., Bonkoungou, M., Boatin, B. and Molyneux, David ORCID: https://orcid.org/0000-0001-8537-7947 (2005) 'Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia'. Tropical Medicine & International Health, Vol 10, Issue 10, pp. 1002-1004.

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Abstract

Ivermectin has been and continues to be extensively used to control onchocerciasis in areas of hyper and mesoendemicity within the African Programme of Onchocerciasis Control. As programmes to eliminate lymphatic filariasis (LF) caused by Wuchereria bancrofti expand, areas of coendemicity with onchocerciasis will be incorporated into LF programmes. This study reports that in villages which were hyperendemic for onchocerciasis after some 14 years of treatment with ivermectin, no W. bancrofti could be detected in a population of 1210 individuals whilst in adjacent villages a prevalence of around 3% was found. Despite the long period of ivermectin treatment Mansonella perstans did not appear to respond to ivermectin in this setting.

Item Type: Article
Additional Information: Freely available via link
Uncontrolled Keywords: wuchereria bancrofti onchocerciasis ivermectin mansonella perstans mansonella-perstans
Subjects: QV Pharmacology > QV 38 Drug action.
QV Pharmacology > QV 4 General works
QV Pharmacology > Drug Standardization. Pharmacognosy. Medicinal Plants > QV 771 Standardization and evaluation of drugs
QX Parasitology > Helminths. Annelida > QX 301 Filarioidea
Faculty: Department: Groups (2002 - 2012) > Disease Control Strategy Group
Digital Object Identifer (DOI): https://doi.org/10.1111/j.1365-3156.2005.01489.x
Depositing User: Sarah Lewis-Newton
Date Deposited: 22 Sep 2011 10:13
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/1984

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