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Analysis of the evolutionary forces shaping mitochondrial genomes of a Neotropical malaria vector complex

Krzywinski, Jaroslaw, Li, Cong, Morris, Marion, Conn, Jan E., Lima, José B., Povoa, Marinete M. and Wilkerson, Richard C. (2011) 'Analysis of the evolutionary forces shaping mitochondrial genomes of a Neotropical malaria vector complex'. Molecular Phylogenetics and Evolution, Vol 58, Issue 3, pp. 469-477.

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Abstract

Many vectors of human malaria belong to complexes of morphologically indistinguishable cryptic species. Here we report the analysis of the newly sequenced complete mitochondrial DNA molecules from six recognized or putative species of one such group, the Neotropical Anopheles albitarsis complex. The molecular evolution of these genomes had been driven by purifying selection, particularly strongly acting on the RNA genes. Directional mutation pressure associated with the strand-asynchronous asymmetric mtDNA replication mechanism may have shaped a pronounced DNA strand asymmetry in the nucleotide composition in these and other Anopheles species. The distribution of sequence polymorphism, coupled with the conflicting phylogenetic trees inferred from the mitochondrial DNA and from the published white gene fragment sequences, indicates that the evolution of the complex may have involved ancient mtDNA introgression. Six protein coding genes (nad5, nad4, cox3, atp6, cox1 and nad2) have high levels of sequence divergence and are likely informative for population genetics studies. Finally, the extent of the mitochondrial DNA variation within the complex supports the notion that the complex consists of a larger number of species than until recently believed.

Item Type: Article
Uncontrolled Keywords: Comparative genomics; Mitochondrial genome evolution; Replication origin; Introgressive hybridization; Malaria vectors
Subjects: QU Biochemistry > Genetics > QU 450 General Works
QX Parasitology > Insects. Other Parasites > QX 515 Anopheles
QX Parasitology > Insects. Other Parasites > QX 650 Insect vectors
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ympev.2011.01.003
Depositing User: Users 183 not found.
Date Deposited: 01 Jun 2011 13:27
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2010

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