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23-Valent pneumococcal polysaccharide vaccine in HIV-infected Ugandan adults: 6-year follow-up of a clinical trial cohort

Watera, C., Nakiyingi, J., Miiro, G., Muwonge, R., Whitworth, J. A. G., Gilks, C.F. and French, Neil (2004) '23-Valent pneumococcal polysaccharide vaccine in HIV-infected Ugandan adults: 6-year follow-up of a clinical trial cohort'. AIDS, Vol 18, Issue 8, pp. 1210-1213.

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Abstract

23-Valent pneumococcal polysaccharide vaccine was previously reported to be ineffective in HIV-infected Ugandan adults. Prolonged follow-up of trial participants confirmed a persistent excess of all-cause pneumonia in vaccine recipients [hazard ratio (HR) 1.6; 95% confidence interval (CI) 1.0-2.4], but surprisingly a survival advantage favouring vaccination (HR 0.84; CI 0.7-1.0). An explanation for the improvement in survival in the face of excess morbid events is lacking; a role for vaccine in HIV care in Africa remains unlikely.

Item Type: Article
Additional Information: Research Letter. This article is available full text from the URL above.
Uncontrolled Keywords: prophylaxis
Subjects: WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
Digital Object Identifer (DOI): https://doi.org/10.1097/01.aids.0000125951.11561.9c
Depositing User: Sarah Lewis-Newton
Date Deposited: 12 Mar 2012 14:47
Last Modified: 21 Nov 2019 14:46
URI: https://archive.lstmed.ac.uk/id/eprint/2104

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