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Relationships between serum concentrations of C-reactive protein and micronutrients, in patients with tuberculosis

Koyanagi, A., Kuffo, D., Gresely, L., Shenkin, A. and Cuevas, Luis (2004) 'Relationships between serum concentrations of C-reactive protein and micronutrients, in patients with tuberculosis'. Annals of Tropical Medicine and Parasitology, Vol 98, Issue 4, pp. 391-399.

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Abstract

Studies on the serum concentrations of micronutrients in tuberculosis (TB), and their relationship to the acute-phase response (APR), are scarce. The serum concentrations of zinc, copper, selenium and vitamins A and E in 46 smear-positive cases of pulmonary TB (PTB) from Ecuador were therefore compared with those in 10 healthy Ecuadorian volunteers, and the correlations between these concentrations and the serum concentration of C-reactive protein (CRP) were evaluated. Compared with the healthy volunteers, the PTB cases had significantly lower serum concentrations of zinc, retinol and selenium and significantly higher serum concentrations of copper. Both groups had moderately high concentrations of selenium in their sera. The PTB cases who had > 50 mg CRP/ litre (a concentration indicative of an APR) had lower serum concentrations of retinol and zinc than the cases with lower CRP concentrations. In patients with PTB, hypozincaemia and hyporetinolaemia are strongly associated with the APR. It is therefore necessary to consider the extent of activation of the APR when interpreting serum micronutrient concentrations in patients with TB.

Item Type: Article
Uncontrolled Keywords: childhood pulmonary tuberculosis acute-phase response tnf-alpha treatment vitamin-a status trace-elements inflammatory response zinc supplementation virus-infection children selenium
Subjects: QY Clinical Pathology > Blood. Blood Chemistry > QY 450 Blood chemistry
WF Respiratory System > Tuberculosis > WF 300 Pulmonary tuberculosis
Faculty: Department: Groups (2002 - 2012) > Child & Reproductive Health Group
Digital Object Identifer (DOI): https://doi.org/10.1179/000349804225003424
Depositing User: Ms Julia Martin
Date Deposited: 28 Feb 2012 10:37
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2116

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