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Wolbachia and cytoplasmic incompatibility in mosquitoes

Sinkins, Steven P. (2004) 'Wolbachia and cytoplasmic incompatibility in mosquitoes'. Insect Biochemistry and Molecular Biology, Vol 34, Issue 7, pp. 723-729.

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Abstract

Wolbachia are maternally inherited bacteria that induce cytoplasmic incompatibility in mosquitoes, and are able to use these patterns of sterility to spread themselves through populations. For this reason they have been proposed as a gene drive system for mosquito genetic replacement, as well as for the reduction of population size or for modulating population age structure in order to reduce disease transmission. Here, recent progress in the study of mosquito Wolbachia is reviewed. We now have much more comprehensive estimates of the parameters that can affect the spread of Wolbachia through natural populations from low starting frequencies. and for waves of spread to be maintained in the face of partial barriers to gene flow. In Aedes albopictits these dynamics are extremely favourable, with very high maternal transmission fidelity and levels of incompatibility recorded. Correspondence between measurements taken in the lab and field is much better than in the Drosophila simulans model system. Important research goals are also discussed, including Wolbachia transformation, interspecific transfer and the elucidation of the mechanisms of incompatibility and rescue; all will be aided by a wealth of new Wolbachia genome information. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: mosquito transgene drive population invasion aedes culex culex-quinquefasciatus diptera superinfected aedes-albopictus wsp gene-sequences drosophila-simulans natural-populations pipiens-fatigans culicidae transmission california arthropods
Subjects: QX Parasitology > Arthropods > QX 460 Arthropods
QX Parasitology > Insects. Other Parasites > QX 510 Mosquitoes
QX Parasitology > Insects. Other Parasites > QX 525 Aedes
QX Parasitology > Insects. Other Parasites > QX 530 Culex
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 880 Filariasis and related conditions (General)
WC Communicable Diseases > Tropical and Parasitic Diseases > WC 885 Onchocerciasis
Faculty: Department: Groups (2002 - 2012) > Vector Group
Digital Object Identifer (DOI): https://doi.org/10.1016/j.ibmb.2004.03.025
Depositing User: Sarah Lewis-Newton
Date Deposited: 03 Jan 2012 11:29
Last Modified: 06 Feb 2018 13:03
URI: http://archive.lstmed.ac.uk/id/eprint/2161

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