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A case-control study to investigate serological correlates of clinical failure of 23-valent pneumococcal polysaccharide vaccine in HIV-1 infected Ugandan adults

French, Neil, Moore, M., Haikala, R., Kayhty, H. and Gilks, C.F. (2004) 'A case-control study to investigate serological correlates of clinical failure of 23-valent pneumococcal polysaccharide vaccine in HIV-1 infected Ugandan adults'. Journal of Infectious Disease, Vol 190, Issue 4, pp. 707-712.

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Abstract

We have investigated the association between the concentration of anti-polysaccharide pneumococcal capsule-specific (anti-PS) immunoglobulin G and the killing activity, in serum, in invasive pneumococcal disease (IPD) events and response to 23-valent polysaccharide vaccine in human immunodeficiency virus (HIV)-infected Ugandans. Case patients with IPD had lower concentrations of anti-PS IgG before and after vaccination and before the IPD event (P < .01 for 5 [i.e., 4, 9V, 14, 18C, and 19F] of 6 serotypes assessed). After vaccination, case patients were less likely than were control subjects to develop detectable serum killing activity against the 2 serotypes tested - for 19F, this activity was detected in 16% of case patients versus 37% of control subjects (P = .08); for 23F, it was detected in 11% of case patients versus 40% of control subjects (P = .02). Thus, absolute concentration of anti-PS IgG and an attenuated response to polysaccharide are associated with risk of IPD in HIV-infected adults.

Item Type: Article
Additional Information: Presented in part: 3rd International Symposium on the Pneumococcus and Pneumococcal Disease, Anchorage, Alaska, 4–8 May 2002.
Subjects: QW Microbiology and Immunology > Reference Works. General Immunology > QW 520 Research (General)
QW Microbiology and Immunology > Immunotherapy and Hypersensitivity > QW 806 Vaccination
WA Public Health > Health Problems of Special Population Groups > WA 395 Health in developing countries
WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections
WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections
Digital Object Identifer (DOI): https://doi.org/10.1086/421911
Depositing User: Martin Chapman
Date Deposited: 28 Feb 2012 17:31
Last Modified: 07 Dec 2018 09:51
URI: https://archive.lstmed.ac.uk/id/eprint/2180

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