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Can mutation and selection explain virulence in human P-falciparum infections?

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Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X, Paget-McNicol, S. and Saul, A. (2004) 'Can mutation and selection explain virulence in human P-falciparum infections?'. Malaria Journal, Vol 3, Issue 2.

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Abstract

Background: Parasites incur periodic mutations which must ultimately be eliminated to maintain their genetic integrity.
Methods: It is hypothesised that these mutations are eliminated not by the conventional mechanisms of competition between parasites in different hosts but primarily by competition between parasites within the same infection.
Results: This process is enhanced by the production of a large number of parasites within individual infections, and this may significantly contribute to parasitic virulence.
Conclusions: Several features of the most virulent human malaria parasite Plasmodium falciparum can usefully be re-interpreted in this light and lend support to this interpretation. More generally, it constitutes a novel explanation for the evolution of virulence in a wider range of microparasites.

Item Type: Article
Uncontrolled Keywords: escherichia-coli antibiotic-resistance antigenic variation malaria parasites adaptation erythrocytes evolution
Subjects: QU Biochemistry > Genetics > QU 475 Genetic processes
QW Microbiology and Immunology > QW 51 Morphology and variability of microorganisms. Microbial genetics.
QX Parasitology > Protozoa > QX 135 Plasmodia
Faculty: Department: Groups (2002 - 2012) > Molecular & Biochemical Parasitology Group
Digital Object Identifer (DOI): https://doi.org/10.1186/1475-2875-3-2
Depositing User: Sarah Lewis-Newton
Date Deposited: 13 Feb 2012 15:44
Last Modified: 06 Feb 2018 13:03
URI: https://archive.lstmed.ac.uk/id/eprint/2200

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